Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel

Abstract

On the isolated guinea-pig papillary muscle heptaminol causes half maximal inotropic effect in a concentration of 4×10−4 M. A variation of the extracellular potassium concentration between 2.4 and 9.6 mM as well as a reduction of the extracellular sodium concentration from 140 mM to 70 mM have no influence on the action of heptaminol; this would have been characteristic for a digitalis-like action. The positive inotropic effect is suppressed by 5×10−4 M propranolol and by pretreatment of the animal with 5 mg/kg reserpine. The action of heptaminol, therefore, is clearly that of an indirectly acting sympathomimetic amine.