DIDS and the Janus-faced Na+-K+-activated ATPase. Focus on “DIDS inhibits Na-K-ATPase activity in porcine nonpigmented ciliary epithelial cells by a Src family kinase-dependent mechanism”

Abstract

the maintenance of mammalian cell volume fundamentally rests on net cation extrusion through Na+-K+-activated ATPase, the Na+ pump. The publication by Shahidullah et al. ([11][1]) persuasively identifies the series of events by which a widely used inhibitor of anion transport, DIDS, can reduce Na+