Diclofenac and ketoprofen toxicity in rat

Abstract

Event Abstract Back to Event Diclofenac and ketoprofen toxicity in rats Zdenko Tomic1, Ana Sabo1, Boris Milijasevic1*, V Jakovljevic1, Aleksandar Raskovic1, Nebojsa Stilinovic1 and Dusan Lalosevic1 1 University of Novi Sad, Department of Pharmacology, Toxycology and Clinical Pharmacology, Serbia Introduction. Diclofenac and ketoprofen are drugs with good therapeutical effect and great consumption. New literature data show increased frequency of acute myocardial infarction with use of these drugs, especially diclofenac, but after use of ketoprofen risk is significantly lower.The aim of study was to investigate influence of diclofenac and ketoprofen on macroscopic and microscopic changes of internal organs and on function of internal organs watching hematocrit, fibrinogen quantity, concentration of Na+ and K+. Methods. The study was performed on mature rats Wistar strain. The animals were divided in seven experimental groups (control group; groups treated with diclofenac and ketoprofen p.o. with one dose; groups treated with diclofenac and ketoprofen p.o. 7 days respectively with 7 doses; groups treated with diclofenac i ketoprofen i.p. 28 days respectively with 28 doses). Results. Diclofenac and ketoprofen were showed toxic effect on treated animals, but in greater percentage diclofenac. There were noticed macroscopic and microscopic changes on internal organs of rats and this changes were more expressed in animals that were receiving diclofenac. Treatment with diclofenac had significant influence on Na+ concentration of investigated animals, in difference to ketoprofen. The increasing concentration of K+ we were noticed in animal serum of group K7 and D28. In all experimental groups there was noticed significant fall of hematocrit values and this appearance was highest in the group that was receiving diclofenac for 7 days. Seven day treatment of rats with diclofenac and ketoprofen produced pathological changes of organs and because of that there was significant increase of fibrinogen values in relation with control. After the 28 days changes of fibrinogen values were not different from control values. Conclusion. On the basis of results we concluded that vital organ changes were more expressed in rats treated with receiving diclofenac in relation with ketoprofen. Keywords: Diclofenac, Ketoprofen, Toxicity, Rats Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Poster Topic: Xenobiotic toxicity Citation: Tomic Z, Sabo A, Milijasevic B, Jakovljevic V, Raskovic A, Stilinovic N and Lalosevic D (2010). Diclofenac and ketoprofen toxicity in rats. Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00205 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Oct 2010; Published Online: 04 Nov 2010. * Correspondence: Dr. Boris Milijasevic, University of Novi Sad, Department of Pharmacology, Toxycology and Clinical Pharmacology, Novi Sad, 21000, Serbia, borismed@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zdenko Tomic Ana Sabo Boris Milijasevic V Jakovljevic Aleksandar Raskovic Nebojsa Stilinovic Dusan Lalosevic Google Zdenko Tomic Ana Sabo Boris Milijasevic V Jakovljevic Aleksandar Raskovic Nebojsa Stilinovic Dusan Lalosevic Google Scholar Zdenko Tomic Ana Sabo Boris Milijasevic V Jakovljevic Aleksandar Raskovic Nebojsa Stilinovic Dusan Lalosevic PubMed Zdenko Tomic Ana Sabo Boris Milijasevic V Jakovljevic Aleksandar Raskovic Nebojsa Stilinovic Dusan Lalosevic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.