Abstract
The structure, dehydration behaviour, and particle characteristics of the two currently available commercial brands of unmilled dicalcium phosphate dihydrate (DCPD) for direct compression, Emcompress and DiTab, were studied. The two brands have very similar properties, differing significantly only in intraparticle porosity. As a consequence, their compression and flow properties are effectively identical. The characteristics of Emcompress and DiTab were compared with those of two DCPD powders, Calipharm (whose properties are typical of milled DCPD preparations) and Kyowa (whose properties are in many respects atypical). It is concluded that the processing undergone by unmilled DCPD for direct compression does not cause major changes in crystal structure, mechanical and surface properties with respect to typical powders. However, there are considerable differences in dehydration behaviour, which can probably be attributed to the larger mean particle size and different particle structure of the direct compression preparations.
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