Abstract
The absorption of rectal diazepam solution was studied in 22 children aged 1–9 yr by measuring serum concentrations. The mean dose was 0.27±0.09mg kg−1. The mean serum concentration was 98.5±53.5 ng ml−1 4min after administration and 206.7±105.8ng ml−1 at 11 min. The correlation between dose and scrum concentration was statistically significant at both times. With a dose of 0.4–0.5 mg kg−1 an adequate serum concentration was achieved within 5–6 min. No side-effects were observed. A rectal solution provides a faster, more effective and reliable alternative to tablets and suppositories, and to the uncertain i.m. injection of diazepam. Meticulous nursing is important.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
