Abstract
In the present experiment we investigate the effects of diazepam on macrophage activity and serum corticosterone levels in mice. Adult mice were treated with diazepam (1.5 mg/kg — group E) or with control solution (group C 1) for 7 days; some animals were only handled, receiving no treatment (group C 2). Oral onco-BCG was used for peritoneal macrophage activation. Diazepam treatment: 1- decreased macrophage spreading and phagocytosis; 2-decreased the concentrations of H 2O 2 spontaneously but not phorbol myristateacetate-induced release. In relation to mice of group C 1, diazepam treatment increased the serum levels of corticosterone. No differences were detected between data of groups C 1 and C 2 both for macrophage activity and serum corticosterone levels. The present data were explained on the basis of a synergistically action for diazepam through peripheral type binding sites (PBR) present in both adrenals and macrophages, stimulating adrenal glucocorticoid production and altering the macrophage cytokine network.
Published Version
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