Abstract
Background: In vertebrates, there are two kinds of myocardium, compacta and spongiosa, which are associated with blood supply systems i.e. coronary and sinusoidal circulation. To characterize the diastolic properties of these two types of ventricles, we analyzed the ventricular end-diastolic pressure-volume relationships (EDPVR) in rat and frog heart that include integrated expression of chamber geometry and passive material properties of myocardial wall.Methods: Pressure of rat left ventricule and frog ventricule was recorded to obtain EDPVRs under isovolumic contractions with increases of ventricular volume to ∼10 mmHg. The curvature changes of EDPVRs were described by non-linear function. (EDP = α•EDV6 + β).Results: Ventricular volumes were normalized by ventricular weights. The volumes from rat and frog ventricles that provided pressure of 10 mmHg were 0.6 and 2.5 mL/g respectively. EDPVRs from rat and frog showed common shape (see Figure). The values of α were 349 ± 39 and 0.677 ± 0.120 (n = 3) in rats and frogs respectively.Discussion: Frog spongy ventricles showed higher expandability than rat left ventricles composed of compact myocardium. Compact myocardium with coronary circulation might trade ventricular expandability in return for higher contractility.View Large Image | View Hi-Res Image | Download PowerPoint Slide
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