Abstract
The reduction of racemic cyclopenta- and cyclohexanone 2-carboxyesters by various yeast and mould strains was shown to produce different amounts of isomeric beta-hydroxyesters with predominant (1 S) stereochemistry. With several strains, only one optically pure cis or trans stereoisomer was obtained in high yield, indicating a diastereoselective and enantioselective reduction.
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