Abstract
up, the CD4 count has increased to 582 and 602 cells/mm in the 1and 2-dose group, respectively; and the proportion of plasma HIV RNA load<20 copies/ml was 83.0 vs 81.6%, respectively, when nearly 100% of the two groups of the patients were receiving cART. Throughout the 5 years of follow-up, the overall serological response rate to serotype 19F remained the lowest. In multivariate analysis, vaccination with 2 doses of PCV7 was statistically significantly associated with significant serological response than vaccination with 1 dose (adjusted odds ratio, 1.73 [95% CI, 1.04-2.89]). Conclusions: Primary vaccination with 2 doses of PCV7 achieves a significantly better serological responses than that with 1 dose among HIV-infected patients throughout the 5 years of follow-up in the era of cART.
Published Version
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