Diallyl Disulfide-Induced Modulation of a Few Phase I and II Drug Metabolizing Enzymes on Aroclor 1254 Toxicity in Rattus norvegicus Liver and Ventral Prostate

Abstract

Polychlorinated biphenyls (PCBs) are persistent bioaccumulative toxicants. These synthetic organochlorinated compounds are well documented for their carcinogenic property, reproductive, neuro, hepato and developmental toxicities. Diallyl disulfide (DADS), a garlic organosulfur compound exerts its effect as a chemopreventive agent via the modulation of drug metabolizing enzymes which has led us to hypothesize that DADS could ameliorate the PCB-induced toxicity in liver and ventral prostate of the rats. In the present investigation, experimentally induced PCB toxicity elevated the activities of phase I enzymes and lipid peroxides level, whereas lowered the levels of phase II enzymes. Oral administration of DADS for 7 days modulated the levels of drug metabolizing enzymes and reduced the lipid peroxides level. These results suggest that PCBs can be readily metabolized by DADS administration through enhancing phase II enzymes thereby it reduces the toxic effects.