Abstract
Osteoporosis is one of the most significant bone complications of cancer. About 1.5 million cancer patients worldwide have bone metastases. Patients with myeloma, breast cancer, prostate, thyroid, bladder and lung have very high risk of development of bone lesions and related complications. Currently, osteodensitometry is the gold standard for the diagnosis of osteoporosis. In recent years we frequently use the innovative imaging techniques for bone metastases, such as CT, MRI, PET/CT. Unfortunately, the diagnostic value of these methods is that it is not always possible to identify abnormalities of bone metabolism in cancer, especially in the early stages. This review shows the world experience of usage of biochemical markers of bone resorption (calcium, hydroxyproline, NTX, CTX, PYD, DPD, TRAP-5b, bone sialoprotein - BSP) and markers of bone synthesis (osteocalcin, CSF, ACF, Karlovy vary IFF), their advantages and disadvantages. The level of these markers is increased in most patients with osteoporosis and bone metastases, it is suggesting a potential role in early diagnosis of bone metastases.
Highlights
Особенностью метаболизма костной ткани является ее перестройка на протяжении всей жизни, поскольку в отличие от других тканей кость обновляется не только заменой «старых» макромолекул вновь синтезируемыми, но реформируется и на морфологическом уровне
Osteodensitometry is the gold standard for the diagnosis of osteoporosis
This review shows the world experience of usage of biochemical markers of bone resorption and markers of bone synthesis, their advantages and disadvantages
Summary
Ключевые слова: остеопороз, диагностика остеопороза, биохимические маркеры, костные метастазы, резорбция костной ткани, синтез костной ткани.
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