Abstract

Diagnostic value of transcranial sonography for patients with Parkinson’s disease in the chinese population:A meta and meta-regression analysis

Highlights

  • Materials and methodsParkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world and is associated with the progressive loss of dopaminergic neurons in the substantia nigra (SN)[1]

  • Group of the Chinese Medical Association Branch of Neurology [14], (3) Original articles provided the extractable data on the diagnostic value of transcranial sonography (TCS) in PD patients

  • In 14 articles, PD patients were diagnosed according to the United Kingdom

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Summary

Introduction

Materials and methodsParkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world and is associated with the progressive loss of dopaminergic neurons in the substantia nigra (SN)[1]. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world and is associated with the progressive loss of dopaminergic neurons in the substantia nigra (SN). A recent clinical pathology study demonstrated that in the early stage of the disease, only 50% PD patients received an accurate diagnosis of PD [3]. To improve the accuracy of the clinical diagnosis, there is a need to have a reliable and practical reference standard. Some articles had reported substantia nigra hyperechogenicity in PD and assessed the diagnostic accuracy of TCS [9,10]. To evaluate the diagnostic accuracy of substantia nigra hyper-echogenicity by transcranial sonography (TCS) for the diagnosis of Parkinson’s disease (PD) in the Chinese population

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