Abstract
BackgroundThe complications of atherosclerosis such as coronary and cerebrovascular disease, are the most prevalent causes of mortality and morbidity worldwide. A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results.MethodsA meta-analysis of eligible studies reporting the association between rs1883832 and atherosclerosis in Chinese population was carried out.ResultsPooling 7 eligible case-control studies involving 2129 patients and 1895 controls demonstrated a significant association between rs1883832 and atherosclerosis under dominant model [odds ratio (OR) = 1.631, 95% confidence interval [CI] [1.176, 2.260] in Chinese population with evident heterogeneity. Meta-regression analysis indicated that the heterogeneity could be completely explained by disease category. In subgroup analysis, rs1883832 conferred ORs of 2.866 (C/C versus T/T, 95%CI [2.203, 3.729]) and 1.680 (C/T versus T/T, 95%CI [1.352, 2.086]) for coronary artery disease (CAD) under co-dominant model without heterogeneity. Similar results were obtained for acute coronary syndrome (ACS) (C/C versus T/T, 3.674, 95%CI [2.638, 5.116]; C/T versus T/T, 1.981, 95%CI [1.483, 2.646]). The other genetic models including dominant, recessive and additive models, yielded consistent results without heterogeneity for CAD and ACS, respectively. However, a protective role was found for C allele in ischemic stroke (IS) under recessive model (0.582, 95%CI [0.393, 0.864]) and additive model (0.785, 95%CI [0.679, 0.909]) with reduced heterogeneity.ConclusionsThis meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
Highlights
Atherosclerosis, with clinical consequences including coronary artery disease (CAD) and ischemic stroke (IS), is one of the leading causes of death worldwide [1]
Published studies based on case-control design assessing the association between rs1883832 (CD40 gene -1C/T) and atherosclerosis; (2) involving subjects restricted to Chinese ethnicity; (3) providing sufficient data for calculating genotypic odds ratio (OR) with corresponding 95% confidence interval
Assessment agreement of study selection between the two reviewers led to a k score of 0.84
Summary
Eligible Studies A total of 156 potential eligible citations were identified with the literature search, among which there were no articles written and published in languages other than English and Chinese. Logistic regression showed that the overall gene effect was statistically significant, with the modified OR1, OR2, and OR3 being 1.896 (1.183, 3.041), 1.474 (1.239, 1.753), and 1.255 (0.841, 1.873), respectively Those results suggested a dominant model of gene effect on atherosclerosis (OR4 1.631, 95% CI [1.176, 2.260]) (figure 2A). Logistic regression showed that the overall gene effect was statistically significant, with the modified OR1, OR2, and OR3 being 0.666 (0.477, 0.930), 1.190 (0.866, 1.635), and 0.562 (0.402, 0.787), respectively Those results suggested a recessive protective model of gene effect on IS (OR5 0.582 95% CI [0.393, 0.864]) (figure 2B). Logistic regression showed that the overall gene effect was statistically significant, with the modified OR1, OR2, and OR3 being 3.674 (2.638, 5.116), 1.981 (1.483, 2.646), and 1.854 (1.428, 2.408), respectively Those results suggested a codominant model of gene effect on ACS (figure 4A and 4B).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
