Diagnostic value of perfusion weighted magnetic resonance imaging in prostate cancer and benign prostatic hyperplasia

Abstract

Objective To evaluate the diagnosis and differential diagnostic value of perfusion weighted magnetic resonance imaging for prostate cancer(PCa)and benign prostatic hyperplasia (BPH).Methods Fifty-three cases were divided into 3 groups:group 1 including 23 cases of PCa,group 2 including 22 cases of BPH,and 8 healthy men enrolled in group 3 as normal control.The differences of perfusion related parameters(including rNEI,rMTE and rMSD)among the 3 groups were studied and analyzed.Results In peripheral zone,the value of rNEI in PCa patients was higher than that in BPH patients(t=11.64,P＜0.001)and control healthy men(t=11.79,P＜0.001).The value of rMTE of PCa patients was lower than that in BPH patients(t=3.50,P=0.002)and control(t=3.78,P=0.001).In central zone,the value of rNEI in PCa patients was higher than that in BPH patients(t=6.99,P＜0.001)and eontrol(t:10.32,P＜0.001).Aceording to ROC,therNEI had the best differential diagnostic value.The optimal threshold was 6.44 with sensitivity of 91.3%and specificity of 81.8%for the PCa differentiation with BPH.Conclusion rNEI is an effectire parameter to differentiate PCa from BPH. Key words: Magnetic resonance imaging; Perfusion weighted imaging; Prostatic carcinoma; Benign prostatic hyperplasia