Abstract
Background: The accumulation of multiple-protein aggregates within muscle fibers is a pathological hallmark of sporadic inclusion body myositis (s-IBM) with the presence of inclusion bodies. Amyloid-beta is one of the accumulated proteins in s-IBM. The aim of this study was to elucidate the utility of Pittsburgh compound B-positron emission tomography (PIB-PET) for diagnosing s-IBM.Methods: Nine patients with s-IBM and four patients with idiopathic inflammatory myopathy (IIM) were included. Patients underwent PIB-PET of body muscles. Standardized uptake values (SUVs) were measured in 16 muscles. A comparison of SUVs was made between s-IBM and IIM groups. The correlation between PIB-PET and clinical parameters was analyzed.Results: The mean SUV of all muscles in s-IBM patients was higher than in IIM patients (0.32 vs. 0.25, respectively; p = 0.031). Subgroup analysis identified a clear difference in SUVs of the forearm and lower-leg muscle groups (p = 0.021 and p = 0.045, respectively). There was no correlation between SUVs and clinical parameters in s-IBM patients.Conclusions: Muscle PIB-PET may help to make a diagnosis of s-IBM.
Highlights
Sporadic inclusion body myositis (s-IBM) is the most frequent progressive muscle disease associated with aging
To visualize the pathological protein in the brain, Pittsburgh compound B-positron emission tomography (PIB-PET) imaging is used as a diagnostic tool for Alzheimer’s disease (AD) [2]
Patients with idiopathic inflammatory myopathy (IIM) consisted of three definite dermatomyositis and one non-specific myositis based on the 2004 European Neuromuscular Center (ENMC) criteria [5]
Summary
Sporadic inclusion body myositis (s-IBM) is the most frequent progressive muscle disease associated with aging. The accumulation of misfolded, ubiquitinated, congophilic, and multiple-protein aggregates within muscle fibers is a pathological hallmark of s-IBM with the presence of inclusion bodies [1]. To visualize the pathological protein in the brain, Pittsburgh compound B-positron emission tomography (PIB-PET) imaging is used as a diagnostic tool for AD [2]. The aim of this study was to elucidate the utility of trunk and limb muscle PIB-PET for the diagnosis of s-IBM. The accumulation of multiple-protein aggregates within muscle fibers is a pathological hallmark of sporadic inclusion body myositis (s-IBM) with the presence of inclusion bodies. The aim of this study was to elucidate the utility of Pittsburgh compound B-positron emission tomography (PIB-PET) for diagnosing s-IBM
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