Diagnostic value of endoscopic ultrasonography on invasive depth of early esophageal cancer: a meta-analysis

Abstract

Objective To evaluate the diagnostic value of endoscopic ultrasonography (EUS) on preoperative invasive depth of early esophageal cancer. Methods A systematic retrieval was performed in PubMed, CNKI and Wangfang databases. Studies on diagnosis of EUS on invasion depth or T1a/T1b stage of early esophageal cancer were retrieved, and related literatures were selected for meta-analysis based on inclusion criteria. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic advantage were calculated, and the receiver operating characteristic curve was drawn to calculate the area under the curve (AUC). Results A total of 20 articles with 1 336 cases were included in the meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and AUC of EUS for T1m staging of early esophageal cancer were 0.86(95%CI: 0.83-0.88), 0.81(95%CI: 0.78-0.85), 4.92(95%CI: 3.02-8.00), 0.19(95%CI: 0.14-0.27), 32.54(95%CI: 15.52-68.25) and 0.923, respectively. For T1sm staging, these results were 0.81(95%CI: 0.78-0.85), 0.86(95%CI: 0.83-0.88), 5.17(95%CI: 3.66-7.32), 0.20(95%CI: 0.13-0.33), 32.02(95%CI: 15.31-66.99) and 0.922, respectively. Conclusion The diagnostic value of EUS is good for early esophageal cancer, and it has a relatively high sensitivity, specificity and AUC for the T1m and T1sm staging. Key words: Endoscopic ultrasonography; Early esophageal carcinoma; Depth; Meta-analysis