Diagnostic value of combined serum CA19-9 with CT scanning in patients with pancreatic cancer

Abstract

Objective To evaluate the diagnostic value of combined serum tumor marker CA19-9 with CT scanning in the patients with pancreatic cancer. Methods A total of 89 patients with suspected pancreatic cancer diagnosed by CT scanning were selected at our hospital from May 2012 to December 2016.The detected results of serum CA19-9 were recorded, and the specificity, sensitivity, positive and negative predictive value of serum CA19-9 in the diagnosis of pancreatic cancer were statistically calculated and analyzed.The correlations between the pre- and post-operative serum levels of CA19-9 and the survival time in pancreatic cancer patients undergoing operation were analyzed. Results The specificity, sensitivity, positive predictive value and negative predictive value of serum CA19-9 combined with CT scanning in the diagnosis of pancreatic cancer were 97.2%, 86.4%, 100.0%, 94.0% respectively.With the increase of preoperative serum levels of CA19-9, the resection rate and median postoperative survival time gradually decreased.Patients with normal serum levels of CA19-9 after operation had longer postoperative survival time than patients with high postoperative serum levels of CA19-9. Conclusions As one of the tumor markers of pancreatic cancer, serum CA19-9 detection has a high diagnostic sensitivity.Combined with CT scanning, serum CA19-9 detection can significantly improve the diagnostic accuracy of pancreatic cancer.Serum CA19-9 can also be used as a mean of efficacy evaluation after radical resection of pancreatic cancer. Key words: Pancreatic neoplasms; Antigens, neoplasm