Diagnostic value of 18F-FDG PET-CT in looking for tumor primary lesion with multiple bone metastasis

Abstract

Objective To evaluate the diagnostic value of 18F-FDG PET-CT in looking for tumor primary lesion with multiple bone metastasis. Methods 84 patients with suspected bone metastases were detected by routine imaging(X-ray,CT,MRI)in our hospital from May 2012 to September 2014 were selected, 18F-FDG PET/CT were used to find the primary lesion. The final diagnosis were confirmed by tissue pathology or by clinical imaging follow-up. The diagnostic sensitivity, specificity and accuracy on tumor bone metastasis of 18F-FDG PET/CT were recorded. Results In 84 patients,primary tumor was found in 49 cases,of which 46 cases(54.8%)confirmed primary tumor by operation or pathology,the other 3 cases were false positive;35 patients were diagnosed as non metastatic bone tumor by PET/CT,in which 34 cases were finally confirmed as non metastatic bone tumor by pathology and follow-up;accuracy,sensitivity,specificity of 18F-FDG PET/CT were 54.8%(46/84),93.9%(46/49)and 95.2% (80/84);18 cases of lung cancer,9 cases of prostate cancer,7 cases of breast cancer,5 cases of lymphoma,4 cases of renal cell carcinoma,2 cases of liver cancer,1 cases of Uterine sarcoma were included in 46 primary tumors. Conclusion 18F-FDG PET/CT has a higher specificity,accuracy as well as higher detection rate in search of multiple bone metastases, thus it is beneficial to the clinical therapy. Key words: Fluorodeoxyglucose F18; Multiple bone metastasis