Abstract
A prothrombin time (PT) derived method has been described to measure plasma fibrinogen concentration. This method is not a direct determination of plasma fibrinogen but an estimation of the fibrinogen concentration from the absorbance changes at 450 nm (delta OD) during the clotting process of the PT on an automated photo optical coagulometers [1,2]. Although this assay is quick, economical and easily available to laboratories with suitable instruments, different papers state opposite conclusions: some studies conclude that the method is accurate and precise for most routine purposes [3] but other authors consider this assay inaccurate and lacks standardization [4,5]. The aims of this study were to compare the results obtained with the determination of fibrinogen by the Clauss and the PT derived methods and to assess the utility of comparison of both methods to identify polymerisation abnormalities.
Published Version
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