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Abstract
BackgroundType 2 diabetes mellitus (T2DM) affects the social economy and quality of life, and has become a major threat to human health. This observation aimed to study the possibility of serum HOTAIR as a diagnostic index in patients with T2DM and to explore the prognostic potential of HOTAIR in the development of T2DM.MethodsThe expression of HOTAIR in serum of 96 patients with T2DM and 82 healthy controls was detected by the qRT-PCR technique. The related biochemical indexes of all participants were determined, such as total cholesterol (TC) and fasting blood glucose (FBG). The value of serum HOTAIR in the diagnosis of T2DM in the two groups was analyzed by the ROC curve. Moreover, the prognostic value of HOTAIR on T2DM was examined by the K-M curve and COX multivariate analysis.ResultsThe results of the qRT-PCR analysis showed that the serum level of HOTAIR in patients with T2DM was significantly higher than that in healthy controls. ROC analysis showed that HOTAIR in serum was a diagnostic factor of T2DM. Further multivariate analysis showed that HOTAIR could be an independent biomarker in the prediction of chronic complications for T2DM patients, such as diabetic retinopathy and diabetic nephropathy.ConclusionsWe found the augment of HOTAIR expression was a character of T2DM. The high expression of serum HOTAIR was a potential non-invasive diagnostic marker and independent prognostic factor in patients with T2DM.
Highlights
Type 2 diabetes mellitus (T2DM) affects the social economy and quality of life, and has become a major threat to human health
The inclusion criteria of the T2DM group were in accordance with the criteria for diagnosis and classification of diabetes recommended by the World Health Organization in 1999, namely fasting venous plasma glucose ≥ 7.0 mmol/L [20]
There were no obvious differences in gender, age, and Body mass index (BMI) between healthy people and the T2DM group (P > 0.05, Table 1)
Summary
Type 2 diabetes mellitus (T2DM) affects the social economy and quality of life, and has become a major threat to human health. This observation aimed to study the possibility of serum HOTAIR as a diagnostic index in patients with T2DM and to explore the prognostic potential of HOTAIR in the development of T2DM. Type 2 diabetes mellitus (T2DM) is a common metabolic disorder in the clinic, characterized by high blood glucose and complex pathogenesis, including insulin-resistant β cell failure [1, 2]. A study finds that lncRNA ENST00000588707.1 is related to glucose metabolism and serves as a feasible biomarker in the field of T2DM [10]. LncRNA NONRATT021972 is at an increased level in patients with T2DM and its interference may release neuropathic pain and inflammation [12]
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