Abstract
Background The diagnostic performance of cardiovascular magnetic resonance (CMR) utilizing adenosine for detection of myocardial ischemia is well established. However, adenosine requires continuous infusion, which is challenging in the CMR environment, and has frequent side effects. The diagnostic accuracy of stress CMR using regadenoson, a newer vasodilator agent that is administered as a single bolus injection and has fewer side effects, has not been well studied. The aims of this study were: (1) to determine the diagnostic accuracy of regadenoson stress CMR when compared to coronary angiography in patients with suspected coronary artery disease (CAD), and (2) to study outcomes in patients with negative stress CMR perfusion studies to confirm that there are not a significant number of “abnormal studies” that are undetected.
Highlights
The diagnostic performance of cardiovascular magnetic resonance (CMR) utilizing adenosine for detection of myocardial ischemia is well established
The aims of this study were: (1) to determine the diagnostic accuracy of regadenoson stress CMR when compared to coronary angiography in patients with suspected coronary artery disease (CAD), and (2) to study outcomes in patients with negative stress CMR perfusion studies to confirm that there are not a significant number of “abnormal studies” that are undetected
We studied 126 patients with suspected CAD referred for regadenoson stress CMR (1.5 T scanner, Philips)
Summary
The diagnostic performance of cardiovascular magnetic resonance (CMR) utilizing adenosine for detection of myocardial ischemia is well established. Adenosine requires continuous infusion, which is challenging in the CMR environment, and has frequent side effects. The diagnostic accuracy of stress CMR using regadenoson, a newer vasodilator agent that is administered as a single bolus injection and has fewer side effects, has not been well studied. The aims of this study were: (1) to determine the diagnostic accuracy of regadenoson stress CMR when compared to coronary angiography in patients with suspected coronary artery disease (CAD), and (2) to study outcomes in patients with negative stress CMR perfusion studies to confirm that there are not a significant number of “abnormal studies” that are undetected
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