Abstract
Diagnosis of cytomegalovirus (CMV) infection in immunocompetent subjects without pregnancy is mainly carried out in clinical situations characterized by a protracted fever, often associated with a mononucleosis syndrome. This clinical presentation is observed during the course of CMV primary infections, since viral reactivations of reinfections remain completely asymptomatic in these subjects. Diagnosis of CMV primary infection in immunocompetent subjects is essentially established by a serodiagnosis based on detection of CMV-specific IgM associated with IgG seroconversion or the presence of low-avidity CMV-specific IgG. In some situations, such as early pre-seroconversion sampling or problem of either false positivity or false negativity of a serological marker, serodiagnosis could be irrelevant. In these cases, the diagnosis of CMV infection is based on viral detection in blood or excretas. CMV viremia is usually low and transient in immunocompetent subjects. CMV DNA detection in peripheral blood leucocytes by PCR represents the most sensitive method to identify CMV in the blood of these patients.
Published Version
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