Abstract
Fine needle aspiration of liver nodules poses several diagnostic challenges. One of the key diagnostic issues is differentiating between well differentiated hepatocellular carcinoma and morphologically similar benign entities. Also challenging is differentiating higher grade hepatocellular carcinomas from other malignancies such as metastatic adenocarcinomas and cholangiocarcinomas. To make an accurate diagnosis, we correlate the clinical history and imaging characteristics of liver nodules with the cytomorphological features and results of ancillary studies. By combining this information, the sensitivity of the fine needle aspiration of liver nodules approaches 92%.1
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