Abstract
Objective: Increased expression of Galectin-3(Gal-3) and Vitronectin (VN) molecules has been the subject of research, since it may be a biological marker that can be used for the separation of benign and malignant tissues. We aimed to evaluate serum Gal-3 and VN expression levels in the presence of thyroid tissue, and evaluate the predictive and prognostic value of these molecules in the differential diagnosis of malignant tissues. Materials and Methods: 44 patients with thyroid nodules were included in this prospective study. Benign and malignant lesions were distinguished from thyroidectomy materials. Results: Mean preoperative Gal-3 and VN values measured in malignant lesions were statistically significantly higher than preoperative Gal-3 and VN values in benign lesions (p-values: 0.007 and 0.009, respectively). Also, mean Gal-3 and VN values measured in serum were significantly reduced after operation compared to preoperative values (p-values
Published Version
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