Abstract
Objectives: Its objective was to assess the performance of CT in diagnosing bladder carcinoma and comparing it with the gold standard – histopathology and to assess the interobserver variability of CT for early detection and staging of the disease. Study design: A cross sectional study. Place and Duration of Study: From January 2023 to June 2023 Diagnostic Radiology Department Bolan Medical Complex Hospital Quetta/ Sandeman Provincial Hospital, Quetta. Methods: The participants for this cross-sectional analysis consisted of 150 patients with clinically suspected bladder carcinoma who had undergone CT scan and transurethral resection of the bladder biopsy. Diagnostic accuracy, sensitivity, specificity and positive and negative predictive values were computed. Descriptive analysis was conducted and p < 0.05 indicated statistical significance, results presented by SD. Results: In 150 patients, CT succeeded in diagnosing bladder carcinoma in 120 cases. 120 histopathological examination showed positive cases according to WHO criteria. The sensitivity of CT was 92.3% and specificity 85%. The coefficient of variation between CT and histopathology in the identification of tumor size was ±0.5 cm. As for diagnostic accuracy, the resulting p-value of 0.03 permits to conclude about the statistical significance of correlations between CT and histopathological findings. Conclusions: Compared to enhanced CT, CT scanning shows great diagnostic efficacy and can be envisaged as a valuable noninvasive diagnostic method for bladder carcinoma, although histopathological examination is indispensable for the definitive diagnosis of the disease. Contrast-enhanced computed tomography (CECT) is especially advantageous in what concerns conducing initial screening, and assessment of the tumor’s stage before operation. Keywords: Bladder carcinoma, CT imaging, histopathology diagnosis and accuracy
Published Version
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