Abstract
Objective To review our experience of managing yolk sac tumors in children. Methods Clinical data of eighteen patients with yolk sac tumors admitted in our department from April 1992 to December 2009 were reviewed retrospectively. There were 12 boys and 6 girls. The diagnoses were based on diagnostic imaging and elevated serum AFP levels. Of the 18 cases, 10 were located in testes,3 in ovaries,4 in sacrococcygeal region and 1 in the abdomen. Results Eleven patients were treated with complete excision and BEP chemotherapy; 5 pateints underwent subtotal resections and chemotherapy; one complete excision without chemotherapy; one patient refused treatment. Followedup of 8-24 months revealed that all children, except for the untreated case, survived uneventfully, without any sign of recurrence or metastasis. Conclusions The combination of surgery and chemotherapy can achieve good prognosis in children with yolk sac tumors. Key words: Yolk sac tumor; Fetoproteins; Prognosis
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