Abstract
Introduction: This study aims to summarize the clinical characteristics of coarctation of the aorta (CoA) associated with intracardiac anomalies in infants.Methods: Medical records of 93 infants who were diagnosed with CoA and intracardiac anomalies from August 2009 to August 2018 were retrospectively reviewed.Results: All of the 93 infants underwent single-stage repair for CoA associated with intracardiac anomalies. The mean operative time was 264.6 ± 57.1 min, and the time of ICU stay was 7.0 ± 4.1 days. The residual transcoarctation pressure gradient before discharge was lower than the pressure gradient prior to surgery (48.3 ± 17.5 vs. 22.4 ± 9.6 mmHg, P < 0.01). Early death before discharge was found in five infants. The mean follow-up time of 88 hospital survivors was 40.0 ± 26.4 months, and no subsequent death occurred in the follow-up. Transcoarctation pressure gradient of the 88 survivors in their last follow-up was 19.6 ± 10.5 mmHg. The pressure gradient of 27 cases was higher than 20 mmHg. Significant lower limb retardation was observed in four cases; therefore, balloon angioplasty consult was recommended. The cumulative recoarctation-free survival rate in 3-year follow-up was 73.5%.Conclusions: To avoid secondary operations in early period, single-stage repair of CoA associated with intracardiac anomalies was effective and safe, and the outcomes in early to mid-term follow-up were satisfactory.
Highlights
This study aims to summarize the clinical characteristics of coarctation of the aorta (CoA) associated with intracardiac anomalies in infants
Poor outcomes are often observed in patients with Coarctation of the aorta (CoA) and intracardiac defects in early age; surgery should be performed in infants or even in neonates
This study aims to review the data regarding single-stage repair of CoA and intracardiac defects in our institution and provide unambiguous evidence that approves the efficacy and safety of single-stage repair
Summary
This study aims to summarize the clinical characteristics of coarctation of the aorta (CoA) associated with intracardiac anomalies in infants. Coarctation of the aorta (CoA) is an unusual congenital heart defect, which accounts for 5–8% in all congenital heart diseases [1,2,3]. Poor outcomes are often observed in patients with CoA and intracardiac defects in early age; surgery should be performed in infants or even in neonates. CoA With Intracardiac Defects in Infants mortality and the incidence of recoarctation between single-stage and two-stage repair. Most medical centers currently prefer single-stage repair for CoA with intracardiac defects [7]. This study aims to review the data regarding single-stage repair of CoA and intracardiac defects in our institution and provide unambiguous evidence that approves the efficacy and safety of single-stage repair
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