Diabetic Peripheral Neuropathy in India and the United States: Clinical Insights from a Comparative Review

Abstract

Abstract Diabetic peripheral neuropathy (DPN) is the most common microvascular complication of diabetes. This review aims to compare the published research on DPN from India and the United States, both having a significant diabetes population and having diverse means and approaches to health care. An online medical database search was conducted on PubMed using the key terms “global prevalence of diabetic neuropathy’, “epidemiology and risk factors of DPN”, “clinical presentation of diabetic neuropathy’, screening and diagnosis of peripheral neuropathy”, “DFU associated with diabetic neuropathy”, and “Charcot neuroarthropathy” from the onset to June 2022. Due to inadequate PubMed citations, a random Google Scholar search was performed. Out of a total of 209 citations (Title/Abstract) that were identified, following a thorough analysis by four different reviewers, 56 citations were chosen, and divided into various categories. Although data shows that DPN is more prevalent in India than in the United States, the former is largely based on clinic or institution-based data with small sample size and thus cannot be meaningfully compared to large population-based data from the United States.