Abstract
Humans build muscle mass over the first two decades of life; begin to lose muscle mass and strength between the third and fourth decades, and the decline accelerates during the sixth decade. Sarcopenia and dynapenia are age-related loss of skeletal muscle mass and muscle strength, respectively.
Highlights
Despite the wealth of information related to sarcopenia and dynapenia [1,2,3,12,13,14,15,16,17,18,19,20,21,22,23,24,25], the specific triggering events associated with loss of skeletal muscle mass and strength in older adults with diabetes remain unknown [3]
The absolute costs associated with diabetes, sarcopenia and dynapenia are likely to rise sharply in the coming decades considering that the total number of persons over 65 years is expected to double over the 20 years (Federal Interagency Forum on Aging-Related Statistics, 2010)
While several studies have investigated the link between changes in skeletal muscle function and mass, skeletal muscle progenitor cells, muscle growth, development, repair, and metabolic activity in different models of diabetes mellitus [1,2,3,12,13,14,15,16,17,18,19,20,21,22,23,24,25], few have examined the impact of hyperglycemic osmotic stress
Summary
Hernández-Ochoa* and Camilo Vanegas Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Sarcopenia and dynapenia are age-related loss of skeletal muscle mass and muscle strength, respectively [1,2,3]. Loss of muscle mass and strength are associated with a reduction in vitality, manifested as poor mobility and physical function [3], and are accentuated by many common chronic diseases including long-term diabetes.
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