Abstract

Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.

Highlights

  • Persons with diabetes are at increased risk of developing microvascular complications such as diabetic retinopathy (DR), a leading cause of blindness, diabetic nephropathy (DN), a leading cause of renal failure, and diabetic peripheral neuropathy (DPN), a leading cause of diabetic foot disorders and lower limb amputations, and all are major causes of morbidity and deaths

  • As many older persons with diabetes are living longer, the prevalence of these microvascular complications is on the rise despite improvements in control of glycemia, blood pressure, and lipid levels. Given that these microvascular complications are largely preventable, it is important to identify novel risk factors or biomarkers associated with early detection of onset/progression of DR, DN, and DPN to mitigate against these microvascular complications

  • Wong and colleagues entitled “Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes” examines the potential for cystatin C to predict DR outcomes better than renal function measures derived from serum creatinine and albuminuria

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Summary

Introduction

Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models Given that these microvascular complications are largely preventable, it is important to identify novel risk factors or biomarkers associated with early detection of onset/progression of DR, DN, and DPN to mitigate against these microvascular complications.

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