Diabetic foot ulcers treatment with silver nanoparticles

Cesar Alejandro Almonaci Hernández,Nina Bogdanchikova,Karla Oyuki Juárez-Moreno,Rosangela López-Acevedo,Martin E Castañeda-Juárez,Horacio Almanza-Reyes,Isis Marion Cabrera Torres,Alexey Pestryakov

doi:10.37636/recit.v212025

Abstract

Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins.

Highlights

Diabetes mellitus (DM) is the second major cause of death in Mexico [1]
AgNPs are spheroidal in morphology, the size distribution goes from 1 to 90 nm with an average size of 35 nm, and their hydrodynamic radio considering both the PVP covering and the metallic silver nanoparticle is 70 nm
We present two clinical cases of successful treatment of diabetic foot ulcers of II degree of Wagner classification with AgNPs topically administered into the wound

Summary

Introduction

Twenty-five percentage of patients with DM developed complications of lower limbs known as diabetic foot ulcers (DFU) [2]. These types of ulcers are characterized by poly-microbial infection, ulceration and destruction of the deepest tissues of lower limbs, associated with neurologic alterations and diverse degrees of peripheral vascular disease [3]. DFU are the main cause of hospitalization and lower limbs amputation [3][5]. If no evidence of healing is shown and complications of the DFU such as gangrene and osteomyelitis are observed, a surgical management is recommended involving the amputation of the lower limb [8]

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