Abstract

Central diabetes insipidus (CDI) is the result of several conditions that affect the hypothalamicneurohypophysis system. Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)]. These adipsic CDI patients are treated with desmopressin and adjusting the amount of daily water intake based on body weight measurement; but controlling the water balance is extremely difficult, and morbidity and mortality are shown to be high in these patients. However, the discovery of the intrinsic property of melanin to dissociate the water molecule marks a before and after in the diagnostic, study, and treatment of patients affected by Central diabetes insipidus. Working on eumelanin has usually been regarded as an intriguing, though sometimes frustrating experience. The molecular mechanism by which eumelanin dissipates the radiation it absorbs was not known until we discovered it (water dissociation) in 2002, during an observational study that began in 1990 and ended in 2002. The working hypothesis was to try to correlate the anatomical characteristics of the blood vessels that enter and leave the optic nerve and the three main causes of blindness in the world. This study allowed us to identify the unsuspected capacity of the human body to transform the energy of sunlight into chemical energy, through the dissociation of the water molecule, as in plants.

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