Abstract
Dexmedetomidine and midazolam have synergistic interaction for the sedative/hypnotic and analgesic effects. The purpose of this study was to assess the type of interaction between dexmedetomidine and midazolam for the immobilizing effect in terms of MAC reduction of either halothane (HAL) or isoflurane (ISO). Fifty-six rats were randomly allocated into one of eight groups (n = 7): SAL + HAL group received saline solution and halothane, SAL + ISO group received saline solution and isoflurane, DEX + HAL group received an intravenous continuous infusion of dexmedetomidine (0.25 μg kg−1minute−1) and halothane, DEX + ISO group received an intravenous continuous infusion of dexmedetomidine (0.25 μg kg−1 minute−1) and isoflurane, MID + HAL group received an intravenous bolus of midazolam (1 mg kg−1) and halothane, MID + ISO group received an intravenous bolus of midazolam (1 mg kg−1) and isoflurane, DEX +MID + HAL group received dexmedetomidine (0.25 μg kg−1 minute−1), midazolam (1 mg kg−1) and halothane and DEX + MID + ISO group received dexmedetomidine (0.25 μg kg−1 minute−1), midazolam (1 mg kg−1) and isoflurane.
Published Version
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