Abstract
Studies have demonstrated that the prolonged use of corticoids can delay the healing process, affecting re-epithelialization, neovascularization and collagen synthesis. As the fins of teleost fish contain a large amount of collagen, the aim of the present study was to investigate the effect of dexamethasone (anti-inflammatory and glucocorticoid steroid widely used in the treatment of rheumatic diseases) during the regeneration process in the caudal fin of specimens of carp (Cyprinus carpio). For such, two glass aquaria were used - one for a group of fish treated with dexamethasone (Henrifarma) in a 20 mg/L concentration and the other for the control group. The caudal fins were amputated transversally and fish remained in their respective aquaria until regeneration occurred. Samples of regenerating fins were collected on days 1, 2, 4, 6, 8 and 10 after amputation. The fins in the control group regenerated normally and grew within the expected in time course. The fins in the group treated with dexamethasone were significantly smaller in comparison to the control group at every evaluation time. Thus, it was possible to verify that, at this concentration of dexamethasone, the regeneration of the caudal fins was delayed, but not completely inhibited. The results show that the caudal fin is a good model for histological studies on regeneration and the action of drug toxicity, but it's also of great importance the interaction with further studies for a better knowledge and understanding of all the changes in all the phases.
Highlights
IntroductionThe anatomy of the teleost fish fins is relatively simple and there are no fundamental morphological or cellular differences among the dorsal, pectoral, pelvic, anal and caudal fins of the same fish (Goodrich, 1904; Prenant, 1936; Blanc, 1947; Grassé, 1958; Lanzing, 1976; Becerra et al, 1983), demonstrating that the development of the fins has been kept the same for over 400 million years of evolution (Mabee et al, 2002)
Each ray is known like lepidotrichium and each lepidotrichium is made up of a pair of elongated and curved structures arranged bilaterally, which are subdivided longitudinally into lepidotrichial hemisegments separated by joints (Arita, 1971), except for the radius side of the caudal fin that does not suffer bifurcation (Akimenko et al, 2003)
The entire intra-lepidotrichial conjunctive tissue, which holds the hemi-segments in place, as well as the skeletal components of the fins contain a large amount of collagen (Becerra et al, 1983)
Summary
The anatomy of the teleost fish fins is relatively simple and there are no fundamental morphological or cellular differences among the dorsal, pectoral, pelvic, anal and caudal fins of the same fish (Goodrich, 1904; Prenant, 1936; Blanc, 1947; Grassé, 1958; Lanzing, 1976; Becerra et al, 1983), demonstrating that the development of the fins has been kept the same for over 400 million years of evolution (Mabee et al, 2002). Fin consist mainly of skeletal elements (rays) covered by skin. These rays originate at the base of the fin and extend distally toward the outer edge (Arita, 1971; Mabee et al, 2002). Two bilateral hemi-segments surround an intra-segmental region, in which nerve bundles, blood vessels and loose conjunctive tissue are found. The entire intra-lepidotrichial conjunctive tissue, which holds the hemi-segments in place, as well as the skeletal components of the fins contain a large amount of collagen (Becerra et al, 1983). Actinotrichia are hyperpolymerized macrofibrils composed of a protein similar to collagen, denominated elastoidin (Becerra et al, 1983; Krukenberg, 1985)
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