Devices for testing tablets with respect to abrasion strength and dissolution rate

Abstract

120 be not less that 97%. No abrasion testing is stipulated for the coated tablets. The standard procedure for determination of the abrasion strength of tablets [ i ] involves rotation of tablets in a special drum and monitoring of the amount of powder formed as a result of mechanical interactions of the tablets with each other and with the drum elements. The pre-existing standard device for the abrasionstrength testing of tablets was recently improved at the Progress Company and is now available in the modified variant. Figure l shows a general outline of the tablet testing device of the UPI type (Russian technical standard TU 9471012-05749470 95). The testing device comprises an electromechanical unit and two drums. The electromechanical unit rotates the drums with tested tablets at a controlled speed and provides necessary supply voltages for the electronic circuit. The front panel of the electromechanical unit contains the following controls: "Power o n o f f " tumbler and the indicator lamp "Mains"; "Time" multiposition switch for selecting the drum rotation time from 1 to 30 min; "Start" button initiating the drum rotation. The rear panel of the electromechanical unit contains the elements of mains connections. The drums are cylinders provided with removable lids. The testing procedure is as follows. According to [ 1 ], ten tablets, cleaned from loose species and weighed with an accuracy of 0.001 g, are placed into the drum and treated for a 5-min time period. When the drum is stopped, the tablets are extracted, cleaned of powdered material, and weighed again to within 0.001 g. The abrasion strength is calculated by the formula