Abstract
A control device has been developed for generating oscillations of dissolved oxygen concentration in fermentation media in order to simulate the conditions in a real production-scale fermentor. Dissolved oxygen concentration is controlled by feeding oxygen and nitrogen at gas feed rates which are set permanently by a personal computer using a simple control algorithm. The dynamic model for the design of the controller takes into account time lags due to dead time, gas phase mixing and oxygen mass transfer as well as the delay of the oxygen probe. The control device was successfully used in gluconic acid fermentations of Aspergillus niger.
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