Abstract
Developmental Changes in the Pituitary-Adrenocortical Axis and Plasma Met-Enkephalin Concentration in Response to Isolation Stress in Growing Lambs
Highlights
The ACTH response increases with lamb age
Plasma concentrations of Met-enkephalin exhibit a biphasic response to stress returning to basal by 60 minutes after onset of isolation stress
What is not known is whether stress influences tissue synthesis and concentrations of enkephalin and how basal plasma concentrations of enkephalin are homeostatically regulated
Summary
The aim of the study was twofold: 1. to determine the development of the pituitary-adrenocortical axis in growing sheep by examining responses to the isolation stress, and 2. to measure the effect of endogenous opioid peptide – Met-enkephalin on the HPA hormones. The aim of the study was twofold: 1. To determine the development of the pituitary-adrenocortical axis in growing sheep by examining responses to the isolation stress, and 2. To measure the effect of endogenous opioid peptide – Met-enkephalin on the HPA hormones. The main aim of the study was to promote the well-being of growing lambs, and to increase our overall understanding of physiological development. The aim of the study was twofold: (1) to determine the development of the pituitary-adrenocortical axis in growing sheep by examining responses to isolation stress, and (2) to estimate the potential impact of stress evoked changes in the endogenous opioid peptide- Met-enkephalin on HPA hormones
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