Abstract
Aflatoxin B1 (AFB1) is regarded as the most toxic mycotoxin and a proven human carcinogen. The development of detection assays for AFB1 is important for human health and environmental protection. In this study, the hollow porous gold nanoflower (HPGN) was synthesized to achieve colorimetric and photothermal performance. Especially, the HPGN exhibited excellent surface-enhanced Raman scattering (SERS) performance by loading with 4-mercaptobenzoic acid (4-MBA), thus SERS determination of AFB1 could be achieved. Compared with gold nanoparticles (AuNPs), the HPGN possessed unique morphology and excellent properties, providing the basis for sensitive and selective AFB1 detection. Under the optimized experimental conditions, the limits of detection (LODs) of lateral flow immunoassay (LFIA) for AFB1 through colorimetric, photothermal and SERS modes were 0.09 ng/mL, 0.09 ng/mL and 0.05 ng/mL, respectively. The tri-mode detection strategy provided a novel concept for immunosensing of mycotoxins or other small molecules.
Published Version
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