Abstract
Mouse IFN inhibited the development of transformed foci in NIH 3T3 cultures transfected with the viral Ha-MuSV( ras ) and Mo-MuSV( mos ) oncogenes, or with the human bladder carcinoma ras EJ T24 DNA. IFN treatment five or seven days after transfection was still effective in inhibiting the oncogenic transformation, but did not inhibit significantly the biochemical transformation induced by pSV2-neo or Ecogpt DNA, so that inhibition of ras -induced transformation was not a result of a general effect on the transfection process. Treatment with IFN did not alter the expression of ras EJ T24 DNA after the transformed phenotype had been established.
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