Development of the Drosophila Optic Lobe.

Abstract

The Drosophila visual system has been a great model to study fundamental questions in neurobiology, such as neural fate specification, axon guidance, circuit formation, and information processing. The Drosophila visual system is composed of the compound eye and the optic lobe. The optic lobe is divided into four neuropils-namely, the lamina, medulla, lobula, and lobula plate. There are around 200 types of optic lobe neurons, which wire together to form a complex neural structure to processes visual information. These neurons are derived from two neuroepithelial structures-namely, the outer proliferation center (OPC) and the inner proliferation center (IPC), in the larval brain. Recent work on the Drosophila optic lobe has revealed basic principles underlying the development of this complex neural structure, and immunostaining has been a key tool in these studies. Here, we provide a brief overview of the Drosophila optic lobe structure and development, as revealed by immunostaining. First, we introduce the structure of the adult optic lobe. Then, we summarize recent advances in the study of neural fate specification during development of different parts of the optic lobe. Last, we briefly summarize general aspects of axon guidance and neuropil assembly in the optic lobe. With this review, we aim to familiarize readers with this complex neural structure and highlight the power of this great model to study neural development to facilitate further developmental and functional studies using this system.