Abstract
Prevention of dental caries involves remineralization of the tooth surfaces with calcium and phosphorus medicines, but the use of fluorine- containing remedies in the form of a cream, gel and varnish is more effective. The aim of our work was to substantiate the composition and technology of a gel with cetylpyridinium hexafluorosilicate having the caries preventive action. A gelling agent – hydroxyethyl cellulose that provides stability and the essential structural and mechanical properties of the gel has been selected experimentally. Microscopic studies have substantiated introduction of the solubilizer PEG-40 hydrogenated castor oil in the concentration of 0.5% that promotes dissolution of the peppermint essential oil with preserving the gel transparency. The use of 10% sorbitol has been substantiated to provide the moderate osmotic properties and to prevent the gel drying. Microbiological studies have shown the necessity of using sodium benzoate as a preservative in the concentration of 0.3%. The temperature regimen of cetylpyridinium hexafluorosilicate introduction in the composition of the gel base has been substantiated by thermogravimetric studies. The technology of gel has been developed.
Highlights
Local prevention of caries consisting in remineralization of the tooth surfaces provides the use of remedies containing calcium and phosphorus (solutions of calcium gluconate (2.5-10%), calcium, and magnesium sulphate used on electrophoresis or as applications) [6]
According to the results of the previous studies hydroxyethyl cellulose (HEC) in the concentration of 1.52.0% was selected as a gelling agent [1]
Since cetylpyridinium hexafluorosilicate (CPHFS) affects the viscosity indices of the gels obtained, namely reduces their structural viscosity, it was necessary to conduct the study of gels within this concentration range
Summary
Local prevention of caries consisting in remineralization of the tooth surfaces provides the use of remedies containing calcium and phosphorus (solutions of calcium gluconate (2.5-10%), calcium, and magnesium sulphate used on electrophoresis or as applications) [6] Such drugs as “Belagel Ca/P” (RF) available in the gel form that contains ions of calcium, potassium, sodium, magnesium, chlorine, phosphorus and “Remodent” (Ukraine) derived from the animal bone tissue containing ions of potassium, calcium, sodium, magnesium, manganese, iron, copper, zinc (used in the form of applications) belong to this group of drugs. The predominant majority of drugs for prevention of dental caries contains fluorine [8] These products are produced in the form of a gel, cream and varnish. The necessity in effective prevention of caries and dominance of drugs of foreign production require the creation of effective and available caries preventive medicines
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