Abstract
It is a well known fact that light emitted at a specific wavelength induces fluorescence in the human body. This kind of fluorescence is called autofluorescence. The application of autofluorescence diagnosis, on the other hand, is a more complicated system designed to detect faint autofluorescence inherent in tissues/cells. We have adopted this autofluorescence diagnosis method and developed a new autofluorescence endoscope imaging system called the SAFE-1000. Normal mucosa emitting autofluorescence appears green on the monitor, while abnormal mucosa shows a dark image caused by the lack of autofluorescence.
Highlights
Endoscopic application of fluorescence for medical detection of carcinoma has recently attracted considerable attention
After intravenous administration of these chemical photosensitizers, a patient must remain in a darkened environment until these light sensitive chemicals have metabolized to a safe level
Actual diagnosis via this method is somewhat more difficult due to the fact that fluorescence from the photosensitizers interferes with the autofluorescence from normal mucosa
Summary
Endoscopic application of fluorescence for medical detection of carcinoma has recently attracted considerable attention. The application of AFD, on the other hand, is a more complicated system designed to detect faint autofluorescence inherent in tissues/cells Since it does not require the use of any photosensitizers, it produces fewer side effects. A greater amount of autofluorescene occurs with normal mucosa and little fluorescene is exhibited by abnormal tissue Applying this same principle, Pentax has developed a new autofluorescence endoscope imaging system (Pentax SAFE-1000) without the application of any photosensitizing agents or use of any laser. By utilizing the same white light used in conventional endoscopy through a pass filter that allows passage of only specific wavelengths, the SAFE1000 collects blue light and delivers it endoscopically to mucosa to excite tissue autofluorescence. The 75 W xenon lamp in the SCH-V2 SAT 1300
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