Development of spectrophotometric method for simultaneous estimation of dexketoprofen and dicyclomine

Abstract

Objectives: The objective of this work was to develop a simple, fast, and reliable ultraviolet (UV) spectrophotometric method for simultaneous estimation of dexketoprofen and dicyclomine in tablet dosage forms. Materials and Methods: Dexketoprofen and dicyclomine solutions were prepared separately in the range of 2 µg/mL–10 µg/mL. The solutions were scanned over a range of 200–400 nm. The isoabsorptive point for both drugs was determined. The developed method was evaluated for accuracy, precision, and linearity. In linearity correlation coefficient was found. Results: A simple, fast, and reliable UV spectrophotometric method was developed for quantitative estimation of dexketoprofen and dicyclomine. The precision study showed that the percent relative standard deviation was within the range of acceptable limits, and the percent recovery was found to be in the range of 0.3–1.5 (intraday) and 0.23–1.7 (interday). In the accuracy study, the percent recovery was found to be 97 (50%), 96 (100%), and 95 (150%). Conclusion: The developed spectrophotometric method in this study was simple, accurate, precise, specific, sensitive, and reproducible and can be directly and easily applied to pharmaceutical dosage forms.