Development of some magnetic metal–organic framework nano composites for pharmaceutical applications

Abstract

• Some novel hydazone complexes were synthesized and characterized. • Antimicrobial activities of the titled compounds were screened. • Interaction of the prepared complexes with CT-DNA was investigated. • Antioxidant and Anticancer activities of the prepared compounds were checked. • Molecular Docking studies were employed to confirm the biological activity. A new series of un-doped and doped magnetite MIL-53 (Fe) series (MIL-53(Fe)/Fe 3 O 4 , MIL-53(Fe)/La-Fe 3 O 4 and MIL-53(Fe)/Gd-Fe 3 O 4 ) were prepared in one-step via solvothermal method. The investigated nanostructured MOFs were characterized by: Fourier Transform Infrared Spectroscopy (FT-IR) analysis, X-ray diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray analysis (EDX), Thermal gravimetric analysis (TGA), and the Nitrogen Adsorption. The results confirm that magnetic MIL-53 MOFs with uniformly distributed of doping ions (La and Gd) with high porosity was successfully prepared. Moreover, the synthesized compounds were evaluated for their in-vitro antimicrobial activity against three pathogenic bacterial strains and three pathogenic fungal strains. The investigated nanomaterials show potent antimicrobial activity against Serratia Marcescence bacteria and Getrichm Candidum fungi. Furthermore, in vitro toxicity of magnetite MIL-53 (Fe) series NPs was investigated on three different cell lines: MCF‐7 cell line (breast carcinoma), Hep-G2 cell line (hepatocellular carcinoma), and HCT-116 cell line (colon carcinoma). These nano MOFs had a high cytotoxic profile against breast cancer cells with IC 50 values up to 11.75 µg·mL 1 , ensuring adequate cell proliferation after 24 h.