Development of pH-sensitive polycaprolactone-based microspheres for in vitro release studies of Triprolidine Hydrochloride

Abstract

A series of different blend ratios of polycaprolactone (PCL) and cellulose acetate phthalate microspheres were prepared by double emulsion solvent evaporation method. Triprolidine hydrochloride (TPH) is propylamine antihistamine drug, which was successfully loaded in to these microspheres via in situ method. The maximum loading of TPH was found to be about 66%. The resulting microspheres were characterized by differential scanning calorimetry (DSC), X-ray diffraction (X-RD), particle size analysis, and scanning electron microscopic (SEM) studies. The DSC study indicates the blend compatibility of polymers. X-RD studies showed that the TPH drug particles are molecularly dispersed in the microspheres. Particle size and SEM studies indicated the formation of spherical microspheres with distinct size. The in vitro release studies revealed that the release of TPH depends upon the pH condition, blend composition, and drug content. The time taken for the release of TPH from microspheres was more than 10 h.