Abstract
β-Cyclodextrin (BCD) and its derivative, Hydroxypropyl-β-Cyclodextrin (HCD) are cyclic oligosaccharides that present the ability to form inclusion complexes (ICs) with hydrophobic molecules and can bring new functionalities to a wide range of materials. As part of this study, water-soluble electrospun nanofibers (NFs) of oseltamivir (OTV) are tested using a variety of protocols in combination with native and its derivatives. There are some limitations to the use of oseltamivir (OTV), an antiviral drug with medium solubility in water. To improve the physical and chemical properties of OTV, β-cyclodextrin:oseltamivir inclusion complexes (OTV:BCD-ICs) and hydroxypropyl-β-cyclodextrin:oseltamivir inclusion complexes (OTV:HCD-ICs) with polyvinyl alcohol mediated nanofibers (OTV:BCD-ICs/PVA NFs, and OTV:HCD-ICs/PVA NFs) are fabricated via electrospinning. ICs are confirmed using several analytical techniques. There are a changes in the chemical shift values after the OTV molecule is introduced into the cavity of both the CDs on the surface of NFs. As shown by scanning electron microscopic images, NFs are homogeneous and particle-free. An analysis of thermogravimetric data indicated that OTV is thermostable after IC formation. Additionally, XPS analysis confirmed the presence of ICs on the surface of NFs. NFs containing OTV:BCD-ICs/PVA had a sustained release of OTV in comparison with NFs containing free material. Based on the dissolution study, the material obtained has no toxic properties and is easily water-soluble. As a result of the fabrication of NFs, OTV is released more rapidly, thus leading to the development of NFs that are non-toxic and water-soluble for creating drug delivery systems.
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