Abstract
Objective: The present study was designed to develop a mucoadhesive tablet of pentoxifylline using the mucoadhesive natural polymer from the plant Manilkara zapota Linn.
 Methods: The tablets were formulated with three different concentrations of the isolated polymer and evaluated for thickness, weight variation, friability, hardness, swelling index, mucoadhesive strength and in vitro drug release. The swelling index was indirectly proportional to the mucoadhesive polymer of Manilkara zapota (MAPMZ) concentration.
 Results: The tablets formulated with a high concentration of MAPMZ showed good mucoadhesion strength in 5 min contact time. The in vitro drug release studies indicated that the drug release was directly proportional to MAPMZ concentration. The release kinetics indicated that the drug release was followed the zero-order.
 Conclusion: The MAPMZ showed the controlled release of pentoxifylline for a period of 12 h.
Highlights
Mucoadhesive drug delivery system has recently gained more interest in pharma profession [1]
Mucoadhesion is a facet of bioadhesion that is aimed to localize the drugs at a certain mucosal area in the body
Three batches of mucoadhesive polymer of Manilkara zapota (MAPMZ) was prepared on a laboratory scale by the method of Rao et al [16]. 200 ml of cold distilled water was added to 20 g of the seed powder and the slurry was prepared
Summary
Mucoadhesive drug delivery system has recently gained more interest in pharma profession [1]. Mucoadhesion is a facet of bioadhesion that is aimed to localize the drugs at a certain mucosal area in the body. Watersoluble polymers, those become adhesive on hydration, has been used to design the formulation. The polymers chosen for mucoadhesion must be nonabsorbable, non-toxic, biocompatible, non-covalent adhesive and economic [4] These polymers may be either natural (sodium alginate, gelatin and guar gum) or synthetic/semi-synthetic (sodium carboxymethyl cellulose, carbopol 934 and hydroxypropyl methylcellulose) [5,6,7,8,9]. They may be used either alone or blends of two or more adhesive polymers for mucoadhesive systems
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