Abstract
The present investigation deals with formulation and development of novel ophthalmic in situ gel formulation of Moxifloxacin in order to treat common disorder of conjunctivitis. The formulation contains combination of two polymers like Poloxamer 4–7 and chitosan both help in sustaining and increasing the drug release as well as retention time of drug at contact site. Thus developed formulation was evaluated for various parameters. The moxifloxacin in situ gel was found to be clear with ph in range of 6.8–7.0. The gelling time was also found to be quick with prolong retention up to 8 hrs. The optimized batch showed maximum release of 99.98% and was found to have sustained action when compared to marketed ophthalmic eye drop formulation. The formulation of Ophthalmic Thermosensitive in situ gel for Moxifloxacin was successfully prepared using Polymer combination of Poloxamer 407 and chitosan and found effective in the treatment of Conjunctivitis.
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