Development of Methods for Obtaining of New Medicines Based on Crataegus submollis Sarg. Fruits

Abstract

In the medical practice the raw materials of various species of the genus Hawthorn (Crataegus sp., Rosaceae family) are widely used. One of the promising species for the use in medicine is Crataegus submollis Sarg. fruits of Crataegus submollis Sarg. which is expediently to process in fresh form for the obtaining of the juice and extraction preparations based on fruit pulp. The hawthorn fruits are characterized on flavonoid composition, both the oxidized ones, flavones and flavonols, such as hyperoside, vitexin, and the reduced forms of flavonoids. i.e. derivatives of catechin (procyanidins), moreover, the last group of flavonoids is the dominant one. It was determined that the contents of the total flavonoids in the fresh, dried fruits of Crataegus submollis Sarg. and dried fruit pulp are 0,38±0,02%, 3,15±0,16% and 3,95±0,20% (calculated on catechin), respectively. The contents of the total flavonoids in the juice, tincture of Crataegus submollis Sarg., tincture based on dried fruit bagasse, as well as in the industrial sample of the tincture of hawthorn fruits are 0,15±0,01%, 0,15±0,01% and 0,12±0,01% (calculated on catechin), respectively.