Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract

Abstract

The aim of the work is to develop the industrial technology of tablets with cardioprotective action based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental samples of mixtures of the plant substance CPHTE (Pastinacae sativae herbae extracti spissi) with excipients approved for medical application were used as objects of the study. Results. The results of experimental studies were used during the development of a block diagram of the technological process to produce tablets with cardioprotective action based on the plant raw material CPHTE and an apparatus scheme was tested in the industrial conditions of LLC “Pharmaceutical Company “Zdorovye” (Kharkiv); the control technological parameters for each stage of the technological process of medicine preparation were established. Conclusions. The technology to produce cardioprotective tablets based on the domestic raw material CPHTE was theoretically substantiated and experimentally developed, as well as a block diagram of the technological process of their production and an apparatus scheme tested in industrial conditions by the LLC “Pharmaceutical Company “Zdorovye” (Kharkiv). The results of the experiment were used while development of projects of quality control methods and technological regulations for the developed medicine in the form of tablets under the conventional name “Pastinocard”.